|
AZD1208
- 英文名称：AZD1208
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B11402
- cas：1204144-28-4
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-04-30
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B11402 |
| 用途 | 科研检测 |
| 英文名称 | AZD1208 |
| 包装规格 | 1MG |
| CAS编号 | 1204144-28-4 |
| 别名 | AZD1208 |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:98% by HPLC;NMR (Conforms)
分子式:C21H21N3O2S
分子量:379.48
溶剂:DMSO (2 mg/mL with warming)
性状:Yellow solid
存储:-20°C
Activity (short version):pan-PIM kinase inhibitor
Function / Pharmacology:AZD1208 is a highly selective and potent pan-PIM kinase inhibitor (IC50 = 3 nM PIM1; 150 nM PIM2; 9 nM PIM3).1 Displayed efficacy in models of acute myeloid leukemia2, prostate cancer3, and triple-negative breast cancer4. Combination treatment of AZD1208 and imatinib eliminated chronic myelogenous leukemia stem cells in cell culture and a patient-derived mouse xenograft model.5 It improved immunotherapeutic antitumor T-cell response6 and disrupted the myeloid cell-mediated immunosuppressive tumor microenvironment increasing T-cell-mediated antitumor immunity.
分子式:C21H21N3O2S
分子量:379.48
溶剂:DMSO (2 mg/mL with warming)
性状:Yellow solid
存储:-20°C
Activity (short version):pan-PIM kinase inhibitor
Function / Pharmacology:AZD1208 is a highly selective and potent pan-PIM kinase inhibitor (IC50 = 3 nM PIM1; 150 nM PIM2; 9 nM PIM3).1 Displayed efficacy in models of acute myeloid leukemia2, prostate cancer3, and triple-negative breast cancer4. Combination treatment of AZD1208 and imatinib eliminated chronic myelogenous leukemia stem cells in cell culture and a patient-derived mouse xenograft model.5 It improved immunotherapeutic antitumor T-cell response6 and disrupted the myeloid cell-mediated immunosuppressive tumor microenvironment increasing T-cell-mediated antitumor immunity.
