纯度:97% by HPLC;NMR (Conforms)
分子式:C26H29N5O2
分子量:443.55
溶剂:DMSO (15 mg/ml) Ethanol (10 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):PDGFR and FLT3 inhibitor
Function / Pharmacology:Crenolanib is a potent inhibitor of PDGFR (Kd for α = 2.1 nM; ? = 3.2 nM) and FLT3 (Kd = 0.74 nM).1 Crenolanib is a type I inhibitor binding only to the active kinase conformation. It showed potent activity against imatinib-resistant PDGFRα mutations D842I, D842V, D842Y, DI842-843M, and deletion I8432 as well as FLT3/ITD and FLT3/D835 mutants3. Crenolanib acted synergistically with FLT3-CAR T-cells in a FLT3-ITD+ AML murine xenograft model.4