|
Crenolanib
- 英文名称：Crenolanib
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B11403
- cas：670220-88-9
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-04-30
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B11403 |
| 用途 | 科研检测 |
| 英文名称 | Crenolanib |
| 包装规格 | 1MG |
| CAS编号 | 670220-88-9 |
| 别名 | Crenolanib |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:97% by HPLC;NMR (Conforms)
分子式:C26H29N5O2
分子量:443.55
溶剂:DMSO (15 mg/ml) Ethanol (10 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):PDGFR and FLT3 inhibitor
Function / Pharmacology:Crenolanib is a potent inhibitor of PDGFR (Kd for α = 2.1 nM; ? = 3.2 nM) and FLT3 (Kd = 0.74 nM).1 Crenolanib is a type I inhibitor binding only to the active kinase conformation. It showed potent activity against imatinib-resistant PDGFRα mutations D842I, D842V, D842Y, DI842-843M, and deletion I8432 as well as FLT3/ITD and FLT3/D835 mutants3. Crenolanib acted synergistically with FLT3-CAR T-cells in a FLT3-ITD+ AML murine xenograft model.4
分子式:C26H29N5O2
分子量:443.55
溶剂:DMSO (15 mg/ml) Ethanol (10 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):PDGFR and FLT3 inhibitor
Function / Pharmacology:Crenolanib is a potent inhibitor of PDGFR (Kd for α = 2.1 nM; ? = 3.2 nM) and FLT3 (Kd = 0.74 nM).1 Crenolanib is a type I inhibitor binding only to the active kinase conformation. It showed potent activity against imatinib-resistant PDGFRα mutations D842I, D842V, D842Y, DI842-843M, and deletion I8432 as well as FLT3/ITD and FLT3/D835 mutants3. Crenolanib acted synergistically with FLT3-CAR T-cells in a FLT3-ITD+ AML murine xenograft model.4
