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TGX-221
- 英文名称:TGX-221
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B11404
- cas:663619-89-4
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-04-30
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B11404 |
用途 | 科研检测 |
英文名称 | TGX-221 |
包装规格 | 1MG |
CAS编号 | 663619-89-4 |
别名 | TGX-221 |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:98% by HPLC;NMR (Conforms)
分子式:C21H24N4O2
分子量:364.45
溶剂:DMSO (10 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):Potent and selective PI3K? inhibitor
Function / Pharmacology:TGX-221 is a potent (IC50 = 5 nM) and selective (1000-fold over p110α and p110γ) inhibitor of PI3-kinase isoform p110?.1 Displays anti-thrombotic activity without affecting bleeding time.1,2 It significantly inhibited tumorigenesis in VHL, SETD2, PTEN, and CDKN2A mutated clear cell renal cell carcinoma.3 TGX-221 induced apoptosis in glioblastoma cells and inhibited cell migration and invasion.4
分子式:C21H24N4O2
分子量:364.45
溶剂:DMSO (10 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):Potent and selective PI3K? inhibitor
Function / Pharmacology:TGX-221 is a potent (IC50 = 5 nM) and selective (1000-fold over p110α and p110γ) inhibitor of PI3-kinase isoform p110?.1 Displays anti-thrombotic activity without affecting bleeding time.1,2 It significantly inhibited tumorigenesis in VHL, SETD2, PTEN, and CDKN2A mutated clear cell renal cell carcinoma.3 TGX-221 induced apoptosis in glioblastoma cells and inhibited cell migration and invasion.4