纯度:99% by HPLC;NMR (Conforms)
分子式:C30H34N4O2
分子量:482.62
溶剂:DMSO (5 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):ALK inhibitor
Function / Pharmacology:Alectinib is a potent (IC50 = 1.9 nM) and highly selective ALK inhibitor.1 It blocked phosphorylation of both native ALK and the L1196M, C1156Y, and F1174L mutants. Alectinib has also been shown to inhibit RET kinase (IC50 = 4.8 nM), the RET gatekeeper mutations V804L and V804M, and inhibited the growth of RET fusion positive cells.2 Alectinib is clinically useful in the treatment of ALK-positive Non-Small Cell Lung Cancer. It effectively suppressed cell proliferation and induced apoptosis in a mouse neuroblastoma xenograft.3