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SGC-GAK-1
- 英文名称：SGC-GAK-1
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B11411
- cas：2226517-76-4
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-04-30
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B11411 |
| 用途 | 科研检测 |
| 英文名称 | SGC-GAK-1 |
| 包装规格 | 1MG |
| CAS编号 | 2226517-76-4 |
| 别名 | SGC-GAK-1 |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:99% by HPLC;NMR (Conforms)
分子式:C18H17BrN2O3
分子量:389.25
溶剂:DMSO (>25 mg/ml) Ethanol (10 mg/ml)
性状:Pale yellow solid
存储:-20°C
Activity (short version):Cyclin G Associated Kinase (GAK) inhibitor
Function / Pharmacology:SGC-GAK-1 is a highly potent and selective inhibitor of cyclin G associated kinase (GAK), a member of the numb-associated kinase (NAK) family involved in membrane trafficking and sorting of proteins and is required for the maintenance of centrosome maturation and progression though mitosis. KD = 1.9 nM with >50-fold selectivity against a panel of 400 kinases. It also displayed affinity for RIPK2 (KD = 110 nM) and ADCK3 (KD = 190 nM). SGC-GAK-1 displayed potent cellular activity in HEK293T cells (IC50 = 120 nM) and showed strong growth inhibition in the prostate cancer cell lines LNCaP (IC50 = 0.65 μM) and 22Rv1 (IC50 = 0.17 μM).
分子式:C18H17BrN2O3
分子量:389.25
溶剂:DMSO (>25 mg/ml) Ethanol (10 mg/ml)
性状:Pale yellow solid
存储:-20°C
Activity (short version):Cyclin G Associated Kinase (GAK) inhibitor
Function / Pharmacology:SGC-GAK-1 is a highly potent and selective inhibitor of cyclin G associated kinase (GAK), a member of the numb-associated kinase (NAK) family involved in membrane trafficking and sorting of proteins and is required for the maintenance of centrosome maturation and progression though mitosis. KD = 1.9 nM with >50-fold selectivity against a panel of 400 kinases. It also displayed affinity for RIPK2 (KD = 110 nM) and ADCK3 (KD = 190 nM). SGC-GAK-1 displayed potent cellular activity in HEK293T cells (IC50 = 120 nM) and showed strong growth inhibition in the prostate cancer cell lines LNCaP (IC50 = 0.65 μM) and 22Rv1 (IC50 = 0.17 μM).
