纯度:98% by HPLC;NMR (Conforms)
分子式:C26H23N7O2
分子量:465.52
溶剂:DMSO (>25 mg/ml)
性状:Yellow solid
存储:-20°C
Activity (short version):BTK inhibitor
Function / Pharmacology:Acalabrutinib (1420477-60-6) is a highly selective, potent (IC50 = 3nM), and irreversible inhibitor of Bruton’s tyrosine kinase (BTK).1 Improved target selectivity (especially against TEC family kinases and EGFR) decreased the number of serious side effects observed with Ibrutinib.2 Acalabrutinib significantly inhibits BCR signaling, inhibits tumor proliferation, and reduces tumor burden.3 Clinically useful agent for treating B-cell cancers. BTK has also been shown to have a role in modulating the innate immune system, especially in dendritic cells and macrophages, suggesting a possible role in immunotherapy.4