纯度:98% by HPLC
分子式:C29H32N6O4S
分子量:560.67
溶剂:DMSO (>25 mg/ml)
性状:Off-whtie solid
存储:-20°C
Activity (short version):FLT3 inhibitor
Function / Pharmacology:Quizartinib is a potent and selective inhibitor of FLT3 (Kd = 1.6nM, IC50 = 0.56 nM MV4-11 cells).1 It is in clinical trials for treatment of Acute Myelogenous Leukemia (AML).2,3 Quizartinib priming resulted in prevention of myelosuppression in mice treated with 5-FU and Gemcitabine.4 Quizartinib showed significant reversal of ABCG2-mediated multidrug resistance (@ 3 μM) via antagonism of drug efflux function.5,6