纯度:>98% by HPLC;NMR (Conforms)
分子式:C30H24N8O2
分子量:629.68
溶剂:DMSO (>25 mg/ml)
性状:Pale yellow solid
存储:-20°C
Activity (short version):PI3Kγ inhibitor
Function / Pharmacology:IPI-549 is a potent and highly selective inhibitor of PI3K-? in both biochemical (IC50 = 16 nM) and cellular (IC50 = 12.2 nM) assays.1 Macrophage PI3K-? has been found to be a critical switch between immune stimulation and suppression.2 IPI-549 has been used to reshape tumor immune microenvironments and promote cytotoxic T-cell-mediated tumor regression. Resistance to immune checkpoint blockade in 4T1 and B16-GMCSF tumors was overcome when anti-PD-1 or anti-CTLA4 therapies were combined with PI3K? inhibition via IPI-549.3 IPI-549 mono-treatment also resulted in tumor growth inhibition in several cancer cell lines.3 IPI-549 has also been shown to modulate P-glycoprotein-mediated multidrug resistance.4