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Defactinib
- 英文名称：Defactinib
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B11427
- cas：1073154-85-4
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-05-23
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B11427 |
| 用途 | 科研检测 |
| 英文名称 | Defactinib |
| 包装规格 | 1MG |
| CAS编号 | 1073154-85-4 |
| 别名 | Defactinib |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:98% by HPLC;NMR (Conforms)
分子式:C20H21F3N8O3S
分子量:510.50
溶剂:DMSO (>25 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):FAK inhibitor
Function / Pharmacology:Defactinib (1073154-85-4) is a potent inhibitor of FAK (IC50 = 0.6nM) and Pyk2 (IC50 = 0.6nM).1 It is active in vivo (EC50 = 26nM). FAK inhibition prevents tumor invasion and dissemination rather than tumor size reduction. Defactinib has been shown to preferentially target cancer stem cells in a mouse xenograft model of triple negative breast cancer.2 It is in multiple clinical trials for various cancers3 and in shows synergistic activity when used in combination with checkpoint immunotherapy 4-6.
分子式:C20H21F3N8O3S
分子量:510.50
溶剂:DMSO (>25 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):FAK inhibitor
Function / Pharmacology:Defactinib (1073154-85-4) is a potent inhibitor of FAK (IC50 = 0.6nM) and Pyk2 (IC50 = 0.6nM).1 It is active in vivo (EC50 = 26nM). FAK inhibition prevents tumor invasion and dissemination rather than tumor size reduction. Defactinib has been shown to preferentially target cancer stem cells in a mouse xenograft model of triple negative breast cancer.2 It is in multiple clinical trials for various cancers3 and in shows synergistic activity when used in combination with checkpoint immunotherapy 4-6.
