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WP1066
- 英文名称：WP1066
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B11429
- cas：857064-38-1
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-04-30
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B11429 |
| 用途 | 科研检测 |
| 英文名称 | WP1066 |
| 包装规格 | 1MG |
| CAS编号 | 857064-38-1 |
| 别名 | WP1066 |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:98% by HPLC;NMR (Conforms)
分子式:C17H14BrN3O
分子量:356.22
溶剂:DMSO (>25 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):JAK/STAT3 inhibitor
Function / Pharmacology:WP1066 (857064-38-1) is an inhibitor of the JAK2/STAT3 pathway as well as STAT5 and AKT.1,2,3 It downregulated Bcl-XL, Mcl-1, and c-myc while activating Bax and inducing apoptosis.1 Active against human malignant glioma U87-MG (IC50 = 5.6μM) and U373-MG (IC50 = 3.7μM) cells. Enhances T-cell cytotoxicity via inhibition of regulatory T-cells.4,5 WP1066 abrogated PD-L1 expression in lymphoma cell lines.6
分子式:C17H14BrN3O
分子量:356.22
溶剂:DMSO (>25 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):JAK/STAT3 inhibitor
Function / Pharmacology:WP1066 (857064-38-1) is an inhibitor of the JAK2/STAT3 pathway as well as STAT5 and AKT.1,2,3 It downregulated Bcl-XL, Mcl-1, and c-myc while activating Bax and inducing apoptosis.1 Active against human malignant glioma U87-MG (IC50 = 5.6μM) and U373-MG (IC50 = 3.7μM) cells. Enhances T-cell cytotoxicity via inhibition of regulatory T-cells.4,5 WP1066 abrogated PD-L1 expression in lymphoma cell lines.6
