纯度:98% by HPLC;NMR (Conforms)
分子式:C17H14BrN3O
分子量:356.22
溶剂:DMSO (>25 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):JAK/STAT3 inhibitor
Function / Pharmacology:WP1066 (857064-38-1) is an inhibitor of the JAK2/STAT3 pathway as well as STAT5 and AKT.1,2,3 It downregulated Bcl-XL, Mcl-1, and c-myc while activating Bax and inducing apoptosis.1 Active against human malignant glioma U87-MG (IC50 = 5.6μM) and U373-MG (IC50 = 3.7μM) cells. Enhances T-cell cytotoxicity via inhibition of regulatory T-cells.4,5 WP1066 abrogated PD-L1 expression in lymphoma cell lines.6