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RK-33
- 英文名称：RK-33
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B11433
- cas：1070773-09-9
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-05-23
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B11433 |
| 用途 | 科研检测 |
| 英文名称 | RK-33 |
| 包装规格 | 1MG |
| CAS编号 | 1070773-09-9 |
| 别名 | RK-33 |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:98% by HPLC;NMR (Conforms)
分子式:C23H20N6O3
分子量:428.44
溶剂:DMSO (20 mg/ml)
性状:Yellow solid
存储:-20°C
Activity (short version):DDX3 inhibitor
Function / Pharmacology:RK-33 is an inhibitor of the RNA helicase DDX3 – IC50’s = 4.4-8.4 μM in high DDX3 expressing lung cancer cell lines A549, H1299, H23, and H460.1,2 Inhibition of DDX3 led to activation of cell death pathways, inhibition of Wnt pathway signaling, and abrogation of non-homologous end-joining (NHEJ) DNA repair. RK-33 was also active in colorectal cancer 3, prostate cancer4, and medulloblastoma cancer5 cell lines. RK-33 caused radiosensitization in breast cancer through inhibition of mitochondrial translation.6 RK-33 facilitates differentiation in human embryonic stem cells (hESC) and decreases pluripotency markers as well as reducing teratoma formation.7
分子式:C23H20N6O3
分子量:428.44
溶剂:DMSO (20 mg/ml)
性状:Yellow solid
存储:-20°C
Activity (short version):DDX3 inhibitor
Function / Pharmacology:RK-33 is an inhibitor of the RNA helicase DDX3 – IC50’s = 4.4-8.4 μM in high DDX3 expressing lung cancer cell lines A549, H1299, H23, and H460.1,2 Inhibition of DDX3 led to activation of cell death pathways, inhibition of Wnt pathway signaling, and abrogation of non-homologous end-joining (NHEJ) DNA repair. RK-33 was also active in colorectal cancer 3, prostate cancer4, and medulloblastoma cancer5 cell lines. RK-33 caused radiosensitization in breast cancer through inhibition of mitochondrial translation.6 RK-33 facilitates differentiation in human embryonic stem cells (hESC) and decreases pluripotency markers as well as reducing teratoma formation.7
