纯度:>98% by HPLC;NMR (Conforms)
分子式:C20H14ClF2NO5S
分子量:453.84
溶剂:DMSO (>50 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):Potent allosteric ATP-citrate lyase inhibitor
Function / Pharmacology:Potent (IC50 = 2.1 nM ADP-Glo assay; 4.8 nM Oxaloacetate coupled enzyme assay) allosteric inhibitor of ATP-citrate lyase.1 NDI-091143 suppressed growth and clonogenic ability in thyroid cancer cell lines FTC-133 and 8505C.2 It also synergistically potentiated the cytotoxicity of sorafenib.2