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JTE-607
  • 英文名称:JTE-607
  • 品牌:WYTSCI
  • 产地:进口
  • 型号:1MG
  • 货号:WT-AY-B11436
  • cas:188791-09-5
  • 价格: ¥1/mg
  • 发布日期: 2025-04-10
  • 更新日期: 2025-04-30
产品详请
产地 进口
品牌 WYTSCI
货号 WT-AY-B11436
用途 科研检测
英文名称 JTE-607
包装规格 1MG
CAS编号 188791-09-5
别名 JTE-607
纯度 98+%
分子式
是否进口
纯度:98% by HPLC;NMR (Conforms)
分子式:C25H31Cl2N3O5·2HCl
分子量:597.36
溶剂:DMSO (25 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):mRNA processing inhibitor
Function / Pharmacology:JTE-607 inhibits inflammatory cytokine production in human peripheral blood mononuclear cells (PBMC’s) without causing immunosuppression: IC50’s = 11 nM (TNF-?), 5.9 nM (IL-1?), 8.8 nM (IL-6), 7.3 nM (IL-8), and 9.1 nM (IL-10).1 It displayed efficacy in a mouse model of septic shock.2 JTE-607 also showed inhibitory activity against acute myelogenous leukemia cell lines.3,4 Recently, the mechanism of action of JTE-607 (a pro-drug, with the active species being the free acid) has been found to be inhibition of pre-messenger RNA endonuclease Cleavage and Polyadenylation Specificity Factor 3 (CPSF3).5,6 This prevents release of newly synthesized mRNA’s resulting in read-through transcription and the formation of DNA-RNA hybrid R-loop structures. Transcripts down-regulated by JTE-607 were related to DNA damage-based phenotype
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