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JTE-607
- 英文名称:JTE-607
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B11436
- cas:188791-09-5
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-04-30
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B11436 |
用途 | 科研检测 |
英文名称 | JTE-607 |
包装规格 | 1MG |
CAS编号 | 188791-09-5 |
别名 | JTE-607 |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:98% by HPLC;NMR (Conforms)
分子式:C25H31Cl2N3O5·2HCl
分子量:597.36
溶剂:DMSO (25 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):mRNA processing inhibitor
Function / Pharmacology:JTE-607 inhibits inflammatory cytokine production in human peripheral blood mononuclear cells (PBMC’s) without causing immunosuppression: IC50’s = 11 nM (TNF-?), 5.9 nM (IL-1?), 8.8 nM (IL-6), 7.3 nM (IL-8), and 9.1 nM (IL-10).1 It displayed efficacy in a mouse model of septic shock.2 JTE-607 also showed inhibitory activity against acute myelogenous leukemia cell lines.3,4 Recently, the mechanism of action of JTE-607 (a pro-drug, with the active species being the free acid) has been found to be inhibition of pre-messenger RNA endonuclease Cleavage and Polyadenylation Specificity Factor 3 (CPSF3).5,6 This prevents release of newly synthesized mRNA’s resulting in read-through transcription and the formation of DNA-RNA hybrid R-loop structures. Transcripts down-regulated by JTE-607 were related to DNA damage-based phenotype
分子式:C25H31Cl2N3O5·2HCl
分子量:597.36
溶剂:DMSO (25 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):mRNA processing inhibitor
Function / Pharmacology:JTE-607 inhibits inflammatory cytokine production in human peripheral blood mononuclear cells (PBMC’s) without causing immunosuppression: IC50’s = 11 nM (TNF-?), 5.9 nM (IL-1?), 8.8 nM (IL-6), 7.3 nM (IL-8), and 9.1 nM (IL-10).1 It displayed efficacy in a mouse model of septic shock.2 JTE-607 also showed inhibitory activity against acute myelogenous leukemia cell lines.3,4 Recently, the mechanism of action of JTE-607 (a pro-drug, with the active species being the free acid) has been found to be inhibition of pre-messenger RNA endonuclease Cleavage and Polyadenylation Specificity Factor 3 (CPSF3).5,6 This prevents release of newly synthesized mRNA’s resulting in read-through transcription and the formation of DNA-RNA hybrid R-loop structures. Transcripts down-regulated by JTE-607 were related to DNA damage-based phenotype