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LY2090314
- 英文名称：LY2090314
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B11440
- cas：603288-22-8
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-04-30
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B11440 |
| 用途 | 科研检测 |
| 英文名称 | LY2090314 |
| 包装规格 | 1MG |
| CAS编号 | 603288-22-8 |
| 别名 | LY2090314 |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:>98% by HPLC;NMR (Conforms)
分子式:C28H25FN6O3
分子量:512.54
溶剂:DMSO (>20 mg/ml)
性状:Orange solid
存储:-20°C
Activity (short version):Wnt/?-Catenin pathway activator / GSK-3 inhibitor
Function / Pharmacology:Wnt/?-catenin pathway activator. LY2090314 is a highly potent (IC50 = 1.5 nM GSK-3α; 0.9 nM GSK-3?) and selective inhibitor of glycogen synthase-3-kinase (GSK-3).1,2 It stabilized ?-catenin levels and elevated expression of Axin2 leading to tumor growth delays in A375 melanoma xenografts.2 LY2090314 significantly reduced growth in multiple neuroblastoma cell lines.3 It inhibited growth and induced apoptosis in osimertinib-resistant lung cancer cells, specifically those with a mesenchymal phenotype.4
分子式:C28H25FN6O3
分子量:512.54
溶剂:DMSO (>20 mg/ml)
性状:Orange solid
存储:-20°C
Activity (short version):Wnt/?-Catenin pathway activator / GSK-3 inhibitor
Function / Pharmacology:Wnt/?-catenin pathway activator. LY2090314 is a highly potent (IC50 = 1.5 nM GSK-3α; 0.9 nM GSK-3?) and selective inhibitor of glycogen synthase-3-kinase (GSK-3).1,2 It stabilized ?-catenin levels and elevated expression of Axin2 leading to tumor growth delays in A375 melanoma xenografts.2 LY2090314 significantly reduced growth in multiple neuroblastoma cell lines.3 It inhibited growth and induced apoptosis in osimertinib-resistant lung cancer cells, specifically those with a mesenchymal phenotype.4
