纯度:>98% by HPLC;NMR (Conforms)
分子式:C20H26N8O2
分子量:410.48
溶剂:DMSO (>25 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):Highly selective PI4KIII? inhibitor
Function / Pharmacology:UCB9608 is a potent (IC50 = 5 nM), highly selective, and orally bioavailable inhibitor of the phosphatidylinositol kinase PI4KIII?.1 It acts as a potent immunosuppressive agent (IC50 = 37 nM human mixed lymphocyte reaction (HuMLR) assay) and was able to significantly prolong heterotopic allograft retention in a mouse model of cardiac allograft rejection. UCB9608 preserved graft tolerance in mice carrying a heterotopic allogenic heart challenged with host-type melanoma and subsequently treated with antitumor immunotherapy.2 UCB9608 promoted a T cell regulatory phenotype over an effector phenotype.3