纯度:98% by HPLC;NMR (Conforms)
分子式:C18H15N5O6S2
分子量:461.47
溶剂:DMSO (10 mg/ml)
性状:Yellow solid
存储:-20°C
Activity (short version):Necroptosis inhibitor / MLKL inhibitor
Function / Pharmacology:Specifically blocks necroptosis downstream of RIP3 activation by preventing MLKL-RIP3 interaction.1 Displays neuroprotective effects after ischemic brain injury.2 Prevents cystine-starvation-induced necroptosis and ferroptosis in human triple negative breast cancer cells.3 Binds to gasdermin D inhibiting pyroptosis and associated inflammatory cell death and sepsis.4 Rescues cells from TLR3 ligand-induced death.5