纯度:98% by HPLC;NMR (Conforms)
分子式:C19H17N3O2S2
分子量:383.49
溶剂:DMSO (>25 mg/ml)
性状:Off-white or pale yellow solid
存储:-20°C
Activity (short version):Necroptosis inhibitor / RIP3 inhibitor
Function / Pharmacology:GSK872 is a potent (IC50 = 1.8nM domain binding; IC50 = 1.3 nM kinase activity) and selective inhibitor of receptor interacting protein 3 (RIP3).1 It is able to prevent necroptosis, virus-induced necrosis, and TLR3-induced necrosis.1,2 GSK872 can induce Caspase8-mediated apoptosis at higher concentrations (e.g.3 μM).2