纯度:>98% by TLC;NMR (Conforms)
分子式:C24H19ClN4O2
分子量:430.89
溶剂:DMSO (30 mg/ml)
性状:Pale yellow solid
存储:-20°C
Activity (short version):NR2E3 agonist
Function / Pharmacology:11a is an agonist of the photoreceptor-specific nuclear receptor (NR2E3; PNR; RNR), found in rod photoreceptor cells (EC50 = 141 nM ?-lactamase assay; 35 nM NCOR assay).1 An interesting tool for targeting age-related macular degeneration. 11a was able to increase p53 activation in uterine cancer tumors suggesting NR2E3 agonism as a new anti-cancer strategy.2 A previous study found that cytotoxicity of 11a was due to G1/S phase cell cycle arrest rather than NR2E3 agonism.3