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UNC0379
- 英文名称:UNC0379
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B11447
- cas:1620401-82-2
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-04-30
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B11447 |
用途 | 科研检测 |
英文名称 | UNC0379 |
包装规格 | 1MG |
CAS编号 | 1620401-82-2 |
别名 | UNC0379 |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:98% by TLC;NMR (Conforms)
分子式:C23H35N5O2
分子量:413.56
溶剂:DMSO (>30 mg/ml)
性状:Tan solid
存储:-20°C
Activity (short version):SETD8 inhibitor
Function / Pharmacology:UNC0379 is an inhibitor of the lysine methyltransferase SETD8 with selectivity over 15 other methyltransferases.1 IC50’s = 7.3 μM in a radioactive methyl transfer assay and 9.0 μM in an MCE assay. UNC0379 treatment of SY5Y and NGP neuroblastoma cell lines lead to activation of p53 and decreased tumor growth in an ex-vivo tumorigenicity assay.2
分子式:C23H35N5O2
分子量:413.56
溶剂:DMSO (>30 mg/ml)
性状:Tan solid
存储:-20°C
Activity (short version):SETD8 inhibitor
Function / Pharmacology:UNC0379 is an inhibitor of the lysine methyltransferase SETD8 with selectivity over 15 other methyltransferases.1 IC50’s = 7.3 μM in a radioactive methyl transfer assay and 9.0 μM in an MCE assay. UNC0379 treatment of SY5Y and NGP neuroblastoma cell lines lead to activation of p53 and decreased tumor growth in an ex-vivo tumorigenicity assay.2