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LD2
- 英文名称：LD2
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B11448
- cas：1134334-55-6
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-05-12
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B11448 |
| 用途 | 科研检测 |
| 英文名称 | LD2 |
| 包装规格 | 1MG |
| CAS编号 | 1134334-55-6 |
| 别名 | LD2 |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:>98% by HPLC;NMR (Conforms)
分子式:C12H10ClN3O
分子量:247.68
溶剂:DMSO (40 mg/ml)
性状:Pale yellow solid
存储:-20°C
Activity (short version):PRMT9 inhibitor
Function / Pharmacology:LD2 is a protein arginine N-methyltransferase 9 (PRMT9) inhibitor. It inhibited the viability of leukemia cells (IC50 = 2-7 μM in various cell lines). LD2 promoted DNA damage leading to cyclic GMP-AMP synthase (cGAS) activation and a type I IFN response. LD2 acted synergistically with anti-PD-1 mAb in an A20 lymphoma syngeneic model, an MA9 AML transplant model as well as a humanized AML mouse model. LD2 treatment led to leukemia stem cell ablation as well as an anticancer immune response.
分子式:C12H10ClN3O
分子量:247.68
溶剂:DMSO (40 mg/ml)
性状:Pale yellow solid
存储:-20°C
Activity (short version):PRMT9 inhibitor
Function / Pharmacology:LD2 is a protein arginine N-methyltransferase 9 (PRMT9) inhibitor. It inhibited the viability of leukemia cells (IC50 = 2-7 μM in various cell lines). LD2 promoted DNA damage leading to cyclic GMP-AMP synthase (cGAS) activation and a type I IFN response. LD2 acted synergistically with anti-PD-1 mAb in an A20 lymphoma syngeneic model, an MA9 AML transplant model as well as a humanized AML mouse model. LD2 treatment led to leukemia stem cell ablation as well as an anticancer immune response.
