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TASIN-1
- 英文名称：TASIN-1
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B11451
- cas：1678515-13-3
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-05-23
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B11451 |
| 用途 | 科研检测 |
| 英文名称 | TASIN-1 |
| 包装规格 | 1MG |
| CAS编号 | 1678515-13-3 |
| 别名 | TASIN-1 |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:98% by HPLC;NMR (Conforms)
分子式:C18H28N2O3S·HCl
分子量:388.95
溶剂:DMSO (20 mg/ml)
性状:White or off-white solid
存储:-20°C
Activity (short version):Selectively induces apoptosis in cells with APC truncations
Function / Pharmacology:Selectively induces apoptosis in cells with truncations in the adenomatous polyposis coli (APC) gene (but not normal cells or wild type cancer cells), an important multifunctional tumor suppressor gene.1 IC50 = 70nM for DLD1 cell line. It inhibited cancer cell growth in human tumor xenografts (DLD1 and HT29 tumors) and a genetically engineered mouse model (CPC;Apc) of colorectal cancer. TASIN-1 induces ER stress-dependent JNK activation with ROS production and AKT inhibition via cholesterol depletion.2
分子式:C18H28N2O3S·HCl
分子量:388.95
溶剂:DMSO (20 mg/ml)
性状:White or off-white solid
存储:-20°C
Activity (short version):Selectively induces apoptosis in cells with APC truncations
Function / Pharmacology:Selectively induces apoptosis in cells with truncations in the adenomatous polyposis coli (APC) gene (but not normal cells or wild type cancer cells), an important multifunctional tumor suppressor gene.1 IC50 = 70nM for DLD1 cell line. It inhibited cancer cell growth in human tumor xenografts (DLD1 and HT29 tumors) and a genetically engineered mouse model (CPC;Apc) of colorectal cancer. TASIN-1 induces ER stress-dependent JNK activation with ROS production and AKT inhibition via cholesterol depletion.2
