纯度:>98% by HPLC;NMR (Conforms)
分子式:C23H26N4OS
分子量:406.55
溶剂:DMSO (>25 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):MyD88 inhibitor
Function / Pharmacology:TJ-M2010-5 is an inhibitor of the toll-like receptor(TLR)/adaptor molecule myeloid differentiation factor 88 (MyD88) signaling pathway, crucial for inflammation and associated with the development of many inflammation-related cancers.1 It ameliorates ischemia-reperfusion injury in various organ models including brain2, liver3, and heart4. TJ-M2010-5 also suppressed proliferation, migration, and invasion in MCF-7 and MDA-MB-231 breast cancer cells.5 It prevented colitis-associated colorectal cancer by impairing myeloid-derived suppressor cells.6