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Motolimod
  • 英文名称:Motolimod
  • 品牌:WYTSCI
  • 产地:进口
  • 型号:1MG
  • 货号:WT-AY-B11461
  • cas:926927-61-9
  • 价格: ¥1/mg
  • 发布日期: 2025-04-10
  • 更新日期: 2025-04-30
产品详请
产地 进口
品牌 WYTSCI
货号 WT-AY-B11461
用途 科研检测
英文名称 Motolimod
包装规格 1MG
CAS编号 926927-61-9
别名 Motolimod
纯度 98+%
分子式
是否进口
纯度:98% by HPLC;NMR (Conforms)
分子式:C28H34N4O2
分子量:458.61
溶剂:DMSO (>25 mg/ml)
性状:Off-white or pale yellow solid
存储:-20°C
Activity (short version):TLR8 agonist
Function / Pharmacology:Motolimod (926927-61-9) is a selective Toll-like receptor 8 (TLR8) agonist (EC50 = 100 nM). It stimulates the production of TNFα and IL-12 from monocytes and myeloid dendritic cells. Motolimod also stimulated IFNγ production from NK cells and increased their toxicity against K562 and ADCC by rituximab and trastuzumab.1,2 It induced apoptosis in monocytic myeloid-derived suppressor cells.3 Motolimod is being investigated in combination with other cancer immunotherapies.4,5 Motolimod has also been shown in induce secreted IL-1b and IL-8 via activation of the NLRP3 inflammasome.6
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