纯度:>98% by HPLC;NMR (Conforms)
分子式:C35H46ClN5O9S
分子量:748.29
溶剂:DMSO (>50 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):HCV NS3 protease inhibitor/CRISPR enhancer
Function / Pharmacology:Asunaprevir is a potent hepatitis C virus NS3 protease inhibitor (IC50 = 0.2 – 3.5 nM).1 Asunaprevir was used as part of a repressible Cas9 system (small molecule-assisted shut off – SMASh) capable of degrading newly synthesized Cas9 protein rapidly to precisely control gene editing.2,3 The Asunapreivr/SMASh system has also been using to target endogenous PD-1 protein for proteasomal degradation.4