纯度:98% by HPLC;NMR (Conforms)
分子式:C36H53N7O6
分子量:679.86
溶剂:DMSO (>25 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):Hepatitis C protease inhibitor
Function / Pharmacology:Hepatitis C NS3/4A protease inhibitor that is in clinical use for genotype 1 infections (IC50 = 354 nM genotype 1b replicon cells; IC50 = 280 nM human fetal hepatocytes infected with genotype 1a HCV-positive patient sera).1-3 It has been shown to inhibit SARS-CoV2 proteases MPro (IC50 = 15 μM)4 and 3CLPro (IC50 = 56 μM)5. Telaprevir is also an allosteric inhibitor of DnaK, the bacterial homolog of Hsp70. It enhanced the efficacy of aminoglycoside antibiotics and reduced resistance to the tuberculosis drug rifampin.6