纯度:98% by HPLC;NMR (Conforms)
分子式:C49H54N8O8
分子量:883.02
溶剂:DMSO (>25 mg/ml)
性状:Pale yellow solid
存储:-20°C
Activity (short version):Hepatitis C protease inhibitor
Function / Pharmacology:Velpatasvir is an extremely potent pan-genotypic hepatitis C virus (HCV) NS5A inhibitor.1 It is a component of Epclusa® and Vosevi®, two clinically useful medications with 98% and 97%, respectively, cure rates for HCV. It displayed EC50’s for GTs 1-4, 6a ranging from 6-16 pM, GT5a at 75 pM, and GT6e at 130 pM. Velpatasvir also displayed an excellent barrier to viral resistance. It has been shown in silico, that velpatasvir binds to the SARS-CoV-2 spike protein and may be a potential therapeutic.2