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Anle138b
  • 英文名称:Anle138b
  • 品牌:WYTSCI
  • 产地:进口
  • 型号:1MG
  • 货号:WT-AY-B11468
  • cas:882697-00-9
  • 价格: ¥1/mg
  • 发布日期: 2025-04-10
  • 更新日期: 2025-04-30
产品详请
产地 进口
品牌 WYTSCI
货号 WT-AY-B11468
用途 科研检测
英文名称 Anle138b
包装规格 1MG
CAS编号 882697-00-9
别名 Anle138b
纯度 98+%
分子式
是否进口
纯度:98% by HPLC;NMR (Conforms)
分子式:C16H11BrN2O2
分子量:343.18
溶剂:DMSO (15 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):Protein aggregation inhibitor
Function / Pharmacology:Anle138b is an aggregation inhibitor that modulates the formation of pathological oligomers of both prion and ?-synuclein.1 In mouse models of prion and diseases and Parkinson’s disease, Anle138b strongly inhibited oligomer formation, neuronal degeneration, and disease progression even after disease onset.1,2 Anle138b has delayed disease progression and prevented motor decline in multiple neurodegenerative models.3-6 Treatment of melanoma cells with anle138b caused massive cell death via major dysregulation of autophagy revealing a protective effect of ?-synuclein on autophagy in these cells.7 Orally bioavailable and able to cross the blood-brain barrier.
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