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Apilimod
- 英文名称:Apilimod
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B11482
- cas:541550-19-0
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-04-30
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B11482 |
用途 | 科研检测 |
英文名称 | Apilimod |
包装规格 | 1MG |
CAS编号 | 541550-19-0 |
别名 | Apilimod |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:99% by HPLC;NMR (Conforms)
分子式:C23H26N6O2
分子量:418.5
溶剂:DMSO (>25 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):IL/12 and 23/PIKfyve inhibitor
Function / Pharmacology:Potent (IC50 = 10 nM IFN-g/LPS-stimulated human PMBC’s; IC50 = 1 nM in IFN-g/SAC-stimulated human PMBC’s) IL-12/IL-23 inhibitor downregulating both at the transcriptional level. Suppresses Th1 but not Th2 immune response.1 Inhibition was also observed in human monocytes, monocyte-derived dendritic cells, and THP-1 cells. Apilimod’s mechanism of action is mediation of TLR signaling via inhibition of phosphatidylinositol-3-phosphate 5-kinase (PIKfyve; IC50 = 14 nM).2 It displayed selective cytotoxic activity in B-cell non-Hodgkin lymphoma compared with normal cells.3 Apilimod prevented infection of VSV-ZEBOV and VSV-SARS-CoV-2 (IC50 = 50 nM) as well as SARS-CoV-2 strain 2019-nCoVB/USA-1WA/2020.4
分子式:C23H26N6O2
分子量:418.5
溶剂:DMSO (>25 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):IL/12 and 23/PIKfyve inhibitor
Function / Pharmacology:Potent (IC50 = 10 nM IFN-g/LPS-stimulated human PMBC’s; IC50 = 1 nM in IFN-g/SAC-stimulated human PMBC’s) IL-12/IL-23 inhibitor downregulating both at the transcriptional level. Suppresses Th1 but not Th2 immune response.1 Inhibition was also observed in human monocytes, monocyte-derived dendritic cells, and THP-1 cells. Apilimod’s mechanism of action is mediation of TLR signaling via inhibition of phosphatidylinositol-3-phosphate 5-kinase (PIKfyve; IC50 = 14 nM).2 It displayed selective cytotoxic activity in B-cell non-Hodgkin lymphoma compared with normal cells.3 Apilimod prevented infection of VSV-ZEBOV and VSV-SARS-CoV-2 (IC50 = 50 nM) as well as SARS-CoV-2 strain 2019-nCoVB/USA-1WA/2020.4