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LXG6403
- 英文名称：LXG6403
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B11484
- cas：315705-04-5
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-05-23
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B11484 |
| 用途 | 科研检测 |
| 英文名称 | LXG6403 |
| 包装规格 | 1MG |
| CAS编号 | 315705-04-5 |
| 别名 | LXG6403 |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:98% by TLC;NMR (Conforms)
分子式:C15H15N5OS2
分子量:345.44
溶剂:DMSO (>25 mg/ml)
性状:Off-white/beige/gray solid
存储:-20°C
Activity (short version):Lysyl oxidase inhibitor
Function / Pharmacology:LXG6403 is a potent (IC50 = 1.3 μM) and selective (3.5x over LOXL2 and no inhibition of LOX1) lysyl oxidase (LOX) inhibitor. Active against LOX in multiple cell lines (IC50 <5 μM against MDA-MB-231, HCC143, Hs-578-T, and HCC1937). LXG6403 enhanced chemosensitivity of triple negative breast cancer cells to anthracycline, doxorubicin, cisplatin, and paclitaxel. It inhibited collagen crosslinking and deposition, increased doxorubicin penetration in cells and organoids, inhibited FAK signaling, and potentiated ROS/DNA damage axis in combination with cisplatin. LXG6403 was able to overcome doxorubicin resistance in the TM01278 TNBC PDX model.
分子式:C15H15N5OS2
分子量:345.44
溶剂:DMSO (>25 mg/ml)
性状:Off-white/beige/gray solid
存储:-20°C
Activity (short version):Lysyl oxidase inhibitor
Function / Pharmacology:LXG6403 is a potent (IC50 = 1.3 μM) and selective (3.5x over LOXL2 and no inhibition of LOX1) lysyl oxidase (LOX) inhibitor. Active against LOX in multiple cell lines (IC50 <5 μM against MDA-MB-231, HCC143, Hs-578-T, and HCC1937). LXG6403 enhanced chemosensitivity of triple negative breast cancer cells to anthracycline, doxorubicin, cisplatin, and paclitaxel. It inhibited collagen crosslinking and deposition, increased doxorubicin penetration in cells and organoids, inhibited FAK signaling, and potentiated ROS/DNA damage axis in combination with cisplatin. LXG6403 was able to overcome doxorubicin resistance in the TM01278 TNBC PDX model.
