纯度:>98% by HPLC;NMR (Conforms)
分子式:C21H23BrN6O5S
分子量:551.42
溶剂:DMSO (>25 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):SUMO-activating enzyme (SAE) inhibitor
Function / Pharmacology:ML792 is a potent (IC50’s = 3 nM SUMO1; 11 nM SUMO2) and selective( IC50 = 32 μM for NEDD8-activating enzyme (NAE)) mechanism-based inhibitor of SUMO-activating enzyme (SAE).1 Treatment of multiple cancer cell lines led to failure of mitotic progression and induction of endoreduplication with MYC-amplified cell lines showing higher sensitivity. ML792 inhibited B-cell growth and promoted cell death in Epstein-Barr virus (EBV)-positive B cells and nasopharyngeal carcinoma cells. It also modulated Latent Membrane Protein-1-induced cell migration and cell adhesion suggesting therapeutic potential in treating EBV-associated malignancies.2