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AOH1996
- 英文名称:AOH1996
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B11488
- cas:2089314-64-5
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-04-30
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B11488 |
用途 | 科研检测 |
英文名称 | AOH1996 |
包装规格 | 1MG |
CAS编号 | 2089314-64-5 |
别名 | AOH1996 |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:>98% by HPLC;NMR (Conforms)
分子式:C26H22N2O4
分子量:426.47
溶剂:DMSO (>50 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):PCNA inhibitor
Function / Pharmacology:AOH1996 inhibits proliferating cell nuclear antigen (PCNA), an enzyme critical to DNA replication and repair processes.1 It enhances the interaction between PCNA and RPB1 subunit of RNA polymerase II leading to degradation of RPB1 and collapse of DNA replication forks in transcribed chromatin regions, thus increasing transcription replication stress causing genomic instability and lethal DNA damage. AOH1996 alone or in combination with topoisomerase inhibitor CPT-11 significantly reduced tumor burden in mice with xenograft tumors (neuroblastoma, breast, or small cell lung cancers) with no side effects. Orally bioavailable.
分子式:C26H22N2O4
分子量:426.47
溶剂:DMSO (>50 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):PCNA inhibitor
Function / Pharmacology:AOH1996 inhibits proliferating cell nuclear antigen (PCNA), an enzyme critical to DNA replication and repair processes.1 It enhances the interaction between PCNA and RPB1 subunit of RNA polymerase II leading to degradation of RPB1 and collapse of DNA replication forks in transcribed chromatin regions, thus increasing transcription replication stress causing genomic instability and lethal DNA damage. AOH1996 alone or in combination with topoisomerase inhibitor CPT-11 significantly reduced tumor burden in mice with xenograft tumors (neuroblastoma, breast, or small cell lung cancers) with no side effects. Orally bioavailable.