纯度:>98% by HPLC;NMR (Conforms)
分子式:C27H31NO4S·HCl
分子量:502.07
溶剂:DMSO (50 mg/ml); water (5 mg/ml with warming)
性状:White solid
存储:-20°C
Activity (short version):Sphingosine kinase-1 inhibitor
Function / Pharmacology:PF-543 (1706522-79-3) is a potent (IC50 = 2.0 nM) and selective (>100-fold over SphK2) reversible inhibitor of sphingosine kinase-1 (SphK1).1 It induced autophagy in head and neck squamous cell carcinoma cells.2 PF-543 mitigated pulmonary fibrosis via reducing lung epithelial cell mitochondrial DNA damage and monocyte recruitment.3 It also alleviated sepsis-induced lung injury in an acute ethanol intoxication model in mice.4 PF-543 inhibited cell cycle and tumor growth in a xenograft model of non-small cell lung cancer.5