纯度:98% by HPLC;NMR (Conforms)
分子式:C10H12FN5O4
分子量:285.23
溶剂:DMSO (30 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):DNA synthesis inhibitor
Function / Pharmacology:A synthetic adenosine analog that inhibits DNA biosynthesis and is a clinically useful antineoplastic agent.1 In cells fludarabine accumulates as its 5’-triphosphate (F-ara-ATP) for which the rate-limiting step in formation is the conversion of fludarabine to its monophosphate.2 F-ara-ATP has multiple mechanisms of action including inhibition of ribonucleotide reductase, DNA polymerase, ligase and primase.2 A frequently used agent in myeloablative conditioning regimens for allogeneic hematopoietic cell transplantation.3 Immunosuppressive effects are mediated via inhibition of TNF?-stimulated production of IL-2 and IFN-? through inactivation of NF?B.4 Antagonist at adenosine A1 receptors.5