纯度:>98% by TLC;NMR (Conforms)
分子式:C12H18N4O4
分子量:282.3
溶剂:DMSO (4 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):Topoisomerase II inhibitor
Function / Pharmacology:ICRF-193 is a topoisomerase II poison.1 Toposiomerase poisons are a special subclass of topoisomerase inhibitors that stabilize topoisomerase-DNA strand passing intermediates and thus cause the topoisomerases to become a cytotoxic DNA-damaging agent.1 It readily induces DNA strand breaks in V79 and irs-2 Chinese hamster lung fibroblasts via a novel mechanism.2 Displays cardioprotective (against anthracycline toxicity)3 and anti-inflammatory effects via reduction of IL-1β secretion by macrophages4. An important tool for studying the cellular response to DNA double-strand breaks.5