|
Ponatinib
- 英文名称：Ponatinib
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B11498
- cas：943319-70-8
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-04-30
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B11498 |
| 用途 | 科研检测 |
| 英文名称 | Ponatinib |
| 包装规格 | 1MG |
| CAS编号 | 943319-70-8 |
| 别名 | Ponatinib |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:98% by HPLC;NMR (Conforms)
分子式:C29H27F3N6O
分子量:532.56
溶剂:DMSO (50 mg/ml) Ethanol (25 mg/ml)
性状:Yellow solid
存储:-20°C
Activity (short version):Bcr-Abl and multikinase inhibitor
Function / Pharmacology:Highly potent pan-Bcr-Abl and multikinase inhibitor, suppressing the activity of native Bcr-Abl (IC50=0.37 nM) as well as the mutants T315I (IC50=2 nM), Q252H (IC50=0.44 nM), Y253F (IC50=0.3 nM), M351T (IC50=0.3 nM) and H396P (IC50=0.34 nM).1 Also inhibits PDGFR?, c-Src and c-Kit (IC50=1.1, 5.4 and 12.5 nM respectively)2 as well as FGFR-mediated signaling (IC50<40 nM)3. Protects against influenza A virus-induced death by suppressing cytokine storm in mouse models.4
分子式:C29H27F3N6O
分子量:532.56
溶剂:DMSO (50 mg/ml) Ethanol (25 mg/ml)
性状:Yellow solid
存储:-20°C
Activity (short version):Bcr-Abl and multikinase inhibitor
Function / Pharmacology:Highly potent pan-Bcr-Abl and multikinase inhibitor, suppressing the activity of native Bcr-Abl (IC50=0.37 nM) as well as the mutants T315I (IC50=2 nM), Q252H (IC50=0.44 nM), Y253F (IC50=0.3 nM), M351T (IC50=0.3 nM) and H396P (IC50=0.34 nM).1 Also inhibits PDGFR?, c-Src and c-Kit (IC50=1.1, 5.4 and 12.5 nM respectively)2 as well as FGFR-mediated signaling (IC50<40 nM)3. Protects against influenza A virus-induced death by suppressing cytokine storm in mouse models.4
