纯度:95% by HPLC;NMR (Conforms)
分子式:C37H38N2O6
分子量:606.71
溶剂:DMSO (35 mg/ml) Ethanol (20 mg/ml)
性状:Pale-yellow solid
存储:-20°C
Activity (short version):Autophagy inhibitor with antiviral activity
Function / Pharmacology:A naturally occurring alkaloid from Stephania cepharantha Hayata which possesses a number of pharmacological activities.1 Attenuates LPS-induced expression of TNF-?, IL-6 and IL-1? in macrophages and inhibits NF-?B activation.2 Induces mitophagy possibly by acting at GPR30 in hepatocellular carcinoma.3 Inhibits autophagosome-lysosome fusion and autophagy by downregulation of MYO1C an actin-based motor protein.4 Potently inhibits replication of SARS CoV-2 and homologous viruses.5