纯度:>98% by TLC;NMR (Conforms)
分子式:C7H9N3S2
分子量:199.29
溶剂:DMSO (100 mg/ml); ethanol (10 mg/ml with warming
性状:Beige solid
存储:-20°C
Activity (short version):SARS-CoV viral entry inhibitor
Function / Pharmacology:SSAA09E1 (433212-75-0) is an inhibitor of SARS coronavirus (SARS-CoV) replication by blocking viral entry (EC50=6.7mM). SSAA09E1 was discovered by screening a chemical library for blocking of entry of HIV-1 pseudotyped with SARS-CoV surface glycoprotein S. The compound acts via inhibition of cathepsin L(IC50=5.33 mM), a host protease required for processing of SARS-S during viral entry. Cathepsin B is not inhibited.1 The compound was also shown to inhibit tyrosinase (IC50=0.14 mM).2