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Boceprevir
- 英文名称：Boceprevir
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B11504
- cas：394730-60-0
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-05-23
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B11504 |
| 用途 | 科研检测 |
| 英文名称 | Boceprevir |
| 包装规格 | 1MG |
| CAS编号 | 394730-60-0 |
| 别名 | Boceprevir |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:98% by TLC;NMR (Conforms)
分子式:C27H45N5O5
分子量:519.68
溶剂:DMSO (15 mg/ml)
性状:White or off-white solid
存储:-20°C
Activity (short version):Antiviral, SARS-CoV-2 Mpro inhibitor
Function / Pharmacology:Boceprevir (394730-60-0) directly inhibits Hepatitis C virus (HCV) NS3 protease (overall binding constant for formation of covalent adduct, Ki* = 14 nM; initial inhibition constant Ki = 7.8 μM). This blocks NS3 autoactivation, and subsequent cleavage and maturation of other viral proteins necessary for replisome assembly. This reversible, slow-binding ketoamide also restores host interferon signaling obstructed by HCV, thus reactivating the immune response1. Recently, it was also found to inhibit the key SARS-CoV-2 protease, Mpro (3CLpro) in vitro (Ki = 1.18 μM) and in cells (EC50 = 1.9 μM, virus-induced cytopathic effects (CPE)
分子式:C27H45N5O5
分子量:519.68
溶剂:DMSO (15 mg/ml)
性状:White or off-white solid
存储:-20°C
Activity (short version):Antiviral, SARS-CoV-2 Mpro inhibitor
Function / Pharmacology:Boceprevir (394730-60-0) directly inhibits Hepatitis C virus (HCV) NS3 protease (overall binding constant for formation of covalent adduct, Ki* = 14 nM; initial inhibition constant Ki = 7.8 μM). This blocks NS3 autoactivation, and subsequent cleavage and maturation of other viral proteins necessary for replisome assembly. This reversible, slow-binding ketoamide also restores host interferon signaling obstructed by HCV, thus reactivating the immune response1. Recently, it was also found to inhibit the key SARS-CoV-2 protease, Mpro (3CLpro) in vitro (Ki = 1.18 μM) and in cells (EC50 = 1.9 μM, virus-induced cytopathic effects (CPE)
