![]() |
AS-1949490
- 英文名称:AS-1949490
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B11508
- cas:1203680-76-5
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-04-30
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B11508 |
用途 | 科研检测 |
英文名称 | AS-1949490 |
包装规格 | 1MG |
CAS编号 | 1203680-76-5 |
别名 | AS-1949490 |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:98% by TLC;NMR (Conforms)
分子式:C20H18ClNO2S
分子量:371.88
溶剂:DMSO (40 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):SHIP2 inhibitor
Function / Pharmacology:A potent and selective inhibitor of the intracellular phosphatase SHIP2 (SH2 domain-containing inositol 5'-phosphatase 2), IC50 = 0.62 ?M.1 Displays ca. 30-fold selectivity for SHIP2 over SHIP1. Activates insulin signaling via the Akt pathway in liver and lowers glucose levels in diabetic mice.1,2 Enhances BDNF expression in cultured cortical neurons.3 Ameliorates ROS generation but aggravates apoptosis in CD2AP-deficient mouse podocytes.4
分子式:C20H18ClNO2S
分子量:371.88
溶剂:DMSO (40 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):SHIP2 inhibitor
Function / Pharmacology:A potent and selective inhibitor of the intracellular phosphatase SHIP2 (SH2 domain-containing inositol 5'-phosphatase 2), IC50 = 0.62 ?M.1 Displays ca. 30-fold selectivity for SHIP2 over SHIP1. Activates insulin signaling via the Akt pathway in liver and lowers glucose levels in diabetic mice.1,2 Enhances BDNF expression in cultured cortical neurons.3 Ameliorates ROS generation but aggravates apoptosis in CD2AP-deficient mouse podocytes.4