纯度:98% by TLC;NMR (Conforms)
分子式:C16H10F2N6O
分子量:340.29
溶剂:DMSO (35 mg/ml)
性状:Pale-yellow solid
存储:-20°C
Activity (short version):Mitochondrial protonophore uncoupler
Function / Pharmacology:A mitochondrial protonophore uncoupler with fewer off-target effects (EC50 = 270 nM in L6 myoblast mitochondria.)1,2 Compared to FCCP, an uncoupler of equal potency, BAM15 stimulates a higher maximum rate of mitochondrial respiration and does not depolarize the plasma membrane.2 Stimulates energy expenditure, protects against obesity and improves glycemic control in rodent models.3 Reverses diet-induced obesity and insulin resistance in mice.4 Attenuates transportation-induced apoptosis in iPS-differentiated retinal tissue.5