纯度:98% by HPLC;NMR (Conforms)
分子式:C22H20FN3O2
分子量:377.41
溶剂:DMSO (50 mg/ml)
性状:Yellow solid
存储:-20°C
Activity (short version):GSK-3? inhibitor
Function / Pharmacology:A potent and selective inhibitor of glycogen synthase kinase 3? (GSK-3?) IC50=53 nM which induces neuronal differentiation.1 Activates the Wnt-?-catenin signaling pathway and attenuates tissue plasminogen activator-induced hemorrhagic transformation after acute ischemic stroke in animal models.2 Promoted hair follicle growth in vitro and antagonized the inhibition of hair follicles by dihydrotestosterone.3 Down-regulates Sox9 expression in limbal epithelial stem/progenitor cells leading to increased differentiation.4