纯度:98% by TLC,;NMR (Conforms)
分子式:C21H23N5O3S
分子量:425.50
溶剂:DMSO (15 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):JAK1 inhibitor
Function / Pharmacology:Potent and selective JAK1 inhibitor (IC50s=10, 28, 810 and 116 nM for JAK1, JAK2, JAK3 and TYK2 respectively.2 Displays potent anti-inflammatory activity in various models.1,2 Effective as a monotherapy in patients with active rheumatoid arthritis.3 Reverses oncostatin M-mediated inhibition of rat stem Leydig cell differentiation.4