纯度:>98% by HPLC;NMR (Conforms)
分子式:C11H13N5O4
分子量:279.26
溶剂:DMSO (50 mg/ml), Water (25 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):GMP synthase inhibitor
Function / Pharmacology:Decoyinine is a non-competitive and reversible inhibitor of GMP synthase (GMPS, IC50=17.3 mM).1 GMPS was shown to be a positive regulator of invasiveness in melanoma cells and decoyinine reduced invasion of melanoma cells by 30%.2 Decoyinine reduces intracellular levels of GMP, GDP and GTP. Numerous studies of decoyinine in bacteria have been performed showing that guanylates play key roles in bacterial growth, cell wall biosynthesis, sporulation, and pathogenicity.3-5