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C-DIM 8
- 英文名称：C-DIM 8
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B11521
- cas：151358-47-3
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-04-30
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B11521 |
| 用途 | 科研检测 |
| 英文名称 | C-DIM 8 |
| 包装规格 | 1MG |
| CAS编号 | 151358-47-3 |
| 别名 | C-DIM 8 |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:98% by TLC,;NMR (Conforms)
分子式:C23H18N2O
分子量:338.41
溶剂:DMSO (35 mg/ml) Ethanol (35 mg/ml)
性状:Pink solid
存储:-20°C
Activity (short version):Nur77 antagonist
Function / Pharmacology:C-DIM 8 is an antagonist of the orphan nuclear receptor Nur77 (NR4A1, TR3).1 Induces reactive oxygen species and ER stress in pancreatic cancer cells.2 C-DIM 8 mimics the effect of Nur77 knockdown in non-small-cell lung cancer A549 and H460 cells, inhibiting cell growth and inducing apoptosis which was accompanied by decreased expression of survivin and inhibition of mTORC1 signaling.3 Inhibits the expression of β1- and β3-integrin and blocks integrin-dependent breast cancer cell migration.4 Decreases expression of the histone methyltransferase G9A (EHMT2) in a variety of cancer cell lines.5
分子式:C23H18N2O
分子量:338.41
溶剂:DMSO (35 mg/ml) Ethanol (35 mg/ml)
性状:Pink solid
存储:-20°C
Activity (short version):Nur77 antagonist
Function / Pharmacology:C-DIM 8 is an antagonist of the orphan nuclear receptor Nur77 (NR4A1, TR3).1 Induces reactive oxygen species and ER stress in pancreatic cancer cells.2 C-DIM 8 mimics the effect of Nur77 knockdown in non-small-cell lung cancer A549 and H460 cells, inhibiting cell growth and inducing apoptosis which was accompanied by decreased expression of survivin and inhibition of mTORC1 signaling.3 Inhibits the expression of β1- and β3-integrin and blocks integrin-dependent breast cancer cell migration.4 Decreases expression of the histone methyltransferase G9A (EHMT2) in a variety of cancer cell lines.5
