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DBIC
- 英文名称：DBIC
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B11522
- cas：487026-67-5
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-04-30
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B11522 |
| 用途 | 科研检测 |
| 英文名称 | DBIC |
| 包装规格 | 1MG |
| CAS编号 | 487026-67-5 |
| 别名 | DBIC |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:>98% by TLC;NMR (Conforms)
分子式:C15H12N4O3
分子量:296.29
溶剂:DMSO (30 mg/ml)
性状:Grey solid
存储:-20°C
Activity (short version):DNMT3B S-nitrosylation inhibitor
Function / Pharmacology:Specifically inhibits S-nitrosylation of DNA methyltransferase 3B (DNMT3B) at low concentrations, IC50≤100 nM, without affecting its enzymatic activity. Treatment with DBIC prevents nitric oxide-induced conversion of human colonic adenoma to adenocarcinoma in vitro. Treatment with DBIC strongly attenuates tumor development in a mouse model of carcinogenesis triggered by inflammation-induced NO production. DNMT3B-mediated DNA methylation is regulated by S-nitrosylaton and DBIC represents a new useful tool for studying this system.1 A negative control compound, DBIC-neg2 (Cat # 10-5162) is also available.
分子式:C15H12N4O3
分子量:296.29
溶剂:DMSO (30 mg/ml)
性状:Grey solid
存储:-20°C
Activity (short version):DNMT3B S-nitrosylation inhibitor
Function / Pharmacology:Specifically inhibits S-nitrosylation of DNA methyltransferase 3B (DNMT3B) at low concentrations, IC50≤100 nM, without affecting its enzymatic activity. Treatment with DBIC prevents nitric oxide-induced conversion of human colonic adenoma to adenocarcinoma in vitro. Treatment with DBIC strongly attenuates tumor development in a mouse model of carcinogenesis triggered by inflammation-induced NO production. DNMT3B-mediated DNA methylation is regulated by S-nitrosylaton and DBIC represents a new useful tool for studying this system.1 A negative control compound, DBIC-neg2 (Cat # 10-5162) is also available.
