纯度:>98% by TLC;NMR (Conforms)
分子式:C19H14N2O6
分子量:366.66
溶剂:DMSO (25 mg/ml) Ethanol (25 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):SIRT6 inhibitor
Function / Pharmacology:OSS-128167 (887686-02-4) is an inhibitor of SIRT6 (IC50=89 μM) showing selectivity over SIRT1 and SIRT2 (IC50s=1,578 and 751 μM, respectively).1 In diffuse large B-cell lymphoma cells which overexpress SIRT6, treatment with OSS-128167 resulted in higher rates of apoptosis, arrested cell cycle progression and augmented sensitivity to chemotherapy.2 It exacerbates diabetic cardiomyopathy by aggravating inflammation and oxidative stress in a streptozotocin-induced diabetic mouse model3 and delays peripheral nerve recovery after injury by suppressing migration, phagocytosis and M2-polarization of macrophages4. OSS-128167 promotes cell senescence and aging in myocardial H9c2 cells.5