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ML401
- 英文名称:ML401
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B11536
- cas:1597489-14-9
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-04-30
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B11536 |
用途 | 科研检测 |
英文名称 | ML401 |
包装规格 | 1MG |
CAS编号 | 1597489-14-9 |
别名 | ML401 |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:>98% by TLC;NMR (Conforms)
分子式:C20H20BrClN2O
分子量:419.75
溶剂:DMSO (45 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):EBI2 (GPR183) antagonist
Function / Pharmacology:ML401 is a potent antagonist of GPR183 (IC50 = 1.03 nM), also known as EBI2 or Epstein-Barr virus-induced gene 2. ML401 inhibited 7α,25-dihydroxycholesterol-induced RS11846 cell chemotaxis, IC50=6 nM.1 GPR183 is a key chemotactic receptor guiding B cell localization to appropriate microenvironments for activation and differentiation.2 It also regulates the homeostasis, localization and immunological function of splenic dendritic cells.3 Oxysterols have been shown to be endogenous ligands for GPR183 with 7α,25-dihydroxycholesterol being the most potent (Kd=450 pM).4
分子式:C20H20BrClN2O
分子量:419.75
溶剂:DMSO (45 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):EBI2 (GPR183) antagonist
Function / Pharmacology:ML401 is a potent antagonist of GPR183 (IC50 = 1.03 nM), also known as EBI2 or Epstein-Barr virus-induced gene 2. ML401 inhibited 7α,25-dihydroxycholesterol-induced RS11846 cell chemotaxis, IC50=6 nM.1 GPR183 is a key chemotactic receptor guiding B cell localization to appropriate microenvironments for activation and differentiation.2 It also regulates the homeostasis, localization and immunological function of splenic dendritic cells.3 Oxysterols have been shown to be endogenous ligands for GPR183 with 7α,25-dihydroxycholesterol being the most potent (Kd=450 pM).4