纯度:>98% by HPLC;NMR (Conforms)
分子式:C23H29ClO4
分子量:404.93
溶剂:DMSO (10 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):Mitochondrial cytochrome bc1 complex inhibitor
Function / Pharmacology:Ascochlorin is a novel isoprenoid phenol isolated from Acremonium egyptiacum and other species.1 It is a novel, specific inhibitor of the mitochondrial cytochrome bc1 complex (mitochondrial respiratory chain complex III) acting at both active sites.2 It induces caspase-independent necroptosis in LPS-stimulated RAW 264.7 macrophages3 resulting in anti-inflammatory effects4. Demonstrates substantial antineoplastic effects in a variety of tumor cell lines and mouse models.5