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Tepotinib
- 英文名称：Tepotinib
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B11538
- cas：1100598-32-0
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-04-30
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B11538 |
| 用途 | 科研检测 |
| 英文名称 | Tepotinib |
| 包装规格 | 1MG |
| CAS编号 | 1100598-32-0 |
| 别名 | Tepotinib |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:>98% by TLC;NMR (Conforms)
分子式:C29H28N6O2
分子量:492.58
溶剂:DMSO (17 mg/ml with warming)
性状:White solid
存储:-20°C
Activity (short version):c-Met inhibitor
Function / Pharmacology:Tepotinib is a selective type 1b MET inhibitor. In biochemical assays using His6-tagged recombinant human MET kinase domain, tepotinib inhibited kinase activity in a concentration-dependent manner with IC50=1.8 nM.1 It displays marked antitumor activity in MET-dependent tumor models.2 It crosses the blood-brain barrier and displays intracranial antitumor activity.3 Tepotinib can overcome EGFR inhibitor resistance mediated by aberrant c-Met activation4 and is in clinical use for non-small cell lung cancer harboring MET exon 14 skipping alterations.
分子式:C29H28N6O2
分子量:492.58
溶剂:DMSO (17 mg/ml with warming)
性状:White solid
存储:-20°C
Activity (short version):c-Met inhibitor
Function / Pharmacology:Tepotinib is a selective type 1b MET inhibitor. In biochemical assays using His6-tagged recombinant human MET kinase domain, tepotinib inhibited kinase activity in a concentration-dependent manner with IC50=1.8 nM.1 It displays marked antitumor activity in MET-dependent tumor models.2 It crosses the blood-brain barrier and displays intracranial antitumor activity.3 Tepotinib can overcome EGFR inhibitor resistance mediated by aberrant c-Met activation4 and is in clinical use for non-small cell lung cancer harboring MET exon 14 skipping alterations.
