纯度:>98% by TLC,;NMR (Conforms)
分子式:C8H4Cl2N4
分子量:227.05
溶剂:DMSO (60 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):Protein-RNA binding click probe
Function / Pharmacology:CEP (1838570-66-3) is a clickable electrophilic purine which may be used to directly quantify protein-RNA interaction on proteins via photoaffinity competition with 4-thiouridine-labeled RNA in cells. Employing CEP in a photo-activatable-competition and chemoproteomic enrichment (PACCE) protocol enables functional profiling of canonical RNA-binding domains as well as the discovery of “moonlighting” RNA binding activity in the human proteome. This new methodology represents a chemoproteomic platform for global quantification of protein-RNA binding activity in living cells.